The San Francisco 49ers are hoping that new Offensive Coordinator Mike Martz will be able to re-energize a lackluster offense. Surprise starting QB, J.T. O'Sullivan and the entire Offensive Line are keys to the 49ers' success this season. Will they be able to deliver between the hash marks? Follow all of the action this season with the NFL Sunday Ticket from DIRECTV.
| San Francisco 49ers | ||||||
| Week | Day | Time | Network | Game | VisitorScore | HomeScore |
| Week 1 | Sunday, Sept 7 | 4:15 p.m. | FOX | Arizona Cardinals | 23 |
13 |
| Week 2 | Sunday, Sept 14 | 4:05 p.m. | FOX | at Seattle Seahawks | 33 |
30 |
| Week 3 | Sunday, Sept 21 | 4:05 p.m. | FOX | Detroit Lions | 13 |
31 |
| Week 4 | Sunday, Sept 28 | 1 p.m. | FOX | at New Orleans Saints | 17 |
31 |
| Week 5 | Sunday, Oct 5 | 4:15 p.m. | CBS | New England Patriots | 30 | 21 |
| Week 6 | Sunday, Oct 12 | 4:15 p.m. | FOX | Philadelphia Eagles | 40 |
26 |
| Week 7 | Sunday, Oct 19 | 1 p.m. | FOX | at New York Giants | ||
| Week 8 | Sunday, Oct 26 | 4:15 p.m. | FOX | Seattle Seahawks | ||
| Week 9 | Bye | |||||
| Week 10 | Monday, Nov 10 | 8:30 p.m. | ESPN | at Arizona Cardinals | ||
| Week 11 | Sunday, Nov 16 | 4:05 p.m. | FOX | St. Louis Rams | ||
| Week 12 | Sunday, Nov 23 | 1 p.m. | FOX | at Dallas Cowboys | ||
| Week 13 | Sunday, Nov 30 | 1 p.m. | FOX | at Buffalo Bills | ||
| Week 14 | Sunday, Dec 7 | 4:05 p.m. | CBS | New York Jets | ||
| Week 15 | Sunday, Dec 14 | 1 p.m. | FOX | at Miami Dolphins | ||
| Week 16 | Sunday, Dec 21 | 1 p.m. | FOX | at St. Louis Rams | ||
| Week 17 | Sunday, Dec 28 | 4:15 p.m. | FOX | Washington Redskins | ||
